Enviar artigo por via de e-mail Diastereotopic derivatives of chiral alkoxyisoindolinones
- Autores: Grigoreva T.1, Garabadzhiu A.1, Tribulovich V.1
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Afiliações:
- St. Petersburg State Institute of Technology (Technical University)
- Edição: Volume 86, Nº 11 (2016)
- Páginas: 2454-2461
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/216503
- DOI: https://doi.org/10.1134/S1070363216110098
- ID: 216503
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Resumo
A method for synthesis of 2,3-substituted 3-hydroxyisoindolin-1-one acyl derivatives, modified reactivators of tumor suppressor protein p53, was developed; these compounds were synthesized and characterized. It was shown that diastereomeric esters of Boc-N-protected amino acids, unlike esters with a free amino group, can be preparatively isolated by flash chromatography using achiral media.
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Sobre autores
T. Grigoreva
St. Petersburg State Institute of Technology (Technical University)
Autor responsável pela correspondência
Email: rozentatiana@gmail.com
Rússia, Moskovskii pr. 26, St. Petersburg, 190013
A. Garabadzhiu
St. Petersburg State Institute of Technology (Technical University)
Email: rozentatiana@gmail.com
Rússia, Moskovskii pr. 26, St. Petersburg, 190013
V. Tribulovich
St. Petersburg State Institute of Technology (Technical University)
Email: rozentatiana@gmail.com
Rússia, Moskovskii pr. 26, St. Petersburg, 190013
