Microwave assisted synthesis of substituted (Z)-2-{[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol- 4-yl]methylene}benzofuran-3(2H)-ones and their antimicrobial activity
- Authors: Ashok D.1, Ziauddin M.1,2, Lakshmi B.V.1, Sarasija M.1
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Affiliations:
- Green and Medical Chemistry Laboratory, Department of Chemistry
- Department of Pharmaceutical Sciences, University College of Technology
- Issue: Vol 86, No 7 (2016)
- Pages: 1753-1757
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215845
- DOI: https://doi.org/10.1134/S1070363216070355
- ID: 215845
Cite item
Abstract
Aurones, pyrazole and thiophene scaffolds are known for their potential antimicrobial activity. Herein, we have synthesized hybrid compounds containing three substituted (Z)-2-{[1-phenyl-3-(thiophen-2-yl)- 1H-pyrazol-4-yl]methylene}benzofuran-3(2H)-ones that had been produced from substituted (E)-1-(2-hydroxyphenyl)- 3-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]prop-2-en-1-ones in high yields. All synthesized compounds were tested in vitro for their antimicrobial activity. Several of those demonstrated promising activity against some fungal and bacterial strains.
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About the authors
D. Ashok
Green and Medical Chemistry Laboratory, Department of Chemistry
Author for correspondence.
Email: ashokdou@gmail.com
India, Hyderabad, 500007
M. Ziauddin
Green and Medical Chemistry Laboratory, Department of Chemistry; Department of Pharmaceutical Sciences, University College of Technology
Email: ashokdou@gmail.com
India, Hyderabad, 500007; Hyderabad, 500007
B. Vijaya Lakshmi
Green and Medical Chemistry Laboratory, Department of Chemistry
Email: ashokdou@gmail.com
India, Hyderabad, 500007
M. Sarasija
Green and Medical Chemistry Laboratory, Department of Chemistry
Email: ashokdou@gmail.com
India, Hyderabad, 500007