Microwave assisted synthesis of substituted (Z)-2-{[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol- 4-yl]methylene}benzofuran-3(2H)-ones and their antimicrobial activity
- Авторлар: Ashok D.1, Ziauddin M.1,2, Lakshmi B.1, Sarasija M.1
-
Мекемелер:
- Green and Medical Chemistry Laboratory, Department of Chemistry
- Department of Pharmaceutical Sciences, University College of Technology
- Шығарылым: Том 86, № 7 (2016)
- Беттер: 1753-1757
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215845
- DOI: https://doi.org/10.1134/S1070363216070355
- ID: 215845
Дәйексөз келтіру
Аннотация
Aurones, pyrazole and thiophene scaffolds are known for their potential antimicrobial activity. Herein, we have synthesized hybrid compounds containing three substituted (Z)-2-{[1-phenyl-3-(thiophen-2-yl)- 1H-pyrazol-4-yl]methylene}benzofuran-3(2H)-ones that had been produced from substituted (E)-1-(2-hydroxyphenyl)- 3-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]prop-2-en-1-ones in high yields. All synthesized compounds were tested in vitro for their antimicrobial activity. Several of those demonstrated promising activity against some fungal and bacterial strains.
Негізгі сөздер
Авторлар туралы
D. Ashok
Green and Medical Chemistry Laboratory, Department of Chemistry
Хат алмасуға жауапты Автор.
Email: ashokdou@gmail.com
Үндістан, Hyderabad, 500007
M. Ziauddin
Green and Medical Chemistry Laboratory, Department of Chemistry; Department of Pharmaceutical Sciences, University College of Technology
Email: ashokdou@gmail.com
Үндістан, Hyderabad, 500007; Hyderabad, 500007
B. Lakshmi
Green and Medical Chemistry Laboratory, Department of Chemistry
Email: ashokdou@gmail.com
Үндістан, Hyderabad, 500007
M. Sarasija
Green and Medical Chemistry Laboratory, Department of Chemistry
Email: ashokdou@gmail.com
Үндістан, Hyderabad, 500007
![](/img/style/loading.gif)