Email this article Synthesis of some novel S-alkylated and S-glycosylated hydantoin derivatives containing pyrene moiety
- Authors: Khalifa N.M.1,2, Nossier E.S.3, Al-Omar M.A.1, Amr A.E.1,4
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Affiliations:
- Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy
- Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division
- Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls)
- Applied Organic Chemistry Department
- Issue: Vol 86, No 4 (2016)
- Pages: 919-923
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/214738
- DOI: https://doi.org/10.1134/S1070363216040277
- ID: 214738
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Abstract
3-Aryl-5-[(Z)-pyrenylmethylene]-2-alkylthiohydantoins and 3-Aryl-5-[(Z)-pyrenylmethylene]-2-(D-glycosyl)-2-thiohydantoins functionalized with different aromatic and glycoside substituents have been synthesized by the reaction of (Z)-3-(4-methoxyphenyl)-5-[(pyren-8-yl)methylene]-2-thiohydantoin with alkyl halides, cyclic and acyclic nucleosides via various routes with moderate to good yields and characterized by 1H, 13C NMR and mass spectra and elemental analysis
About the authors
N. M. Khalifa
Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy; Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division
Author for correspondence.
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451; Cairo, Dokki, 12622
E. S. Nossier
Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls)
Email: nagykhalifa@hotmail.com
Egypt, Cairo
M. A. Al-Omar
Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451
A. E. Amr
Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy; Applied Organic Chemistry Department
Email: nagykhalifa@hotmail.com
Saudi Arabia, Riyadh, 11451; Cairo, Dokki, 12622
