New method of preparation of carboxy-protected amino acid conjugates of glycyrrhizinic acid


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Abstract

A method for preparation of carboxy-protected amino acid conjugates of glycyrrhizinic acid with the use of N-hydroxybenzotriazole, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, and methyl esters of L-amino acids (phenylalanine, tyrosine, leucine, isoleucine, and methionine) in 85–90% yield was developed. The structure of the prepared compounds was confirmed by IR and 13C NMR spectra.

About the authors

L. A. Baltina

Ufa Institute of Chemistry of the Russian Academy of Sciences

Author for correspondence.
Email: baltina@anrb.ru
Russian Federation, pr. Oktyabrya 71, Ufa, 450054

A. I. Fairushina

Ufa Institute of Chemistry of the Russian Academy of Sciences

Email: baltina@anrb.ru
Russian Federation, pr. Oktyabrya 71, Ufa, 450054

L. A. Baltina

Ufa Institute of Chemistry of the Russian Academy of Sciences

Email: baltina@anrb.ru
Russian Federation, pr. Oktyabrya 71, Ufa, 450054


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