Email this article Synthesis of novel substituted pyridines from 1-(3-aminophenyl)-3-(1H-indol-3-yl)prop-2-en-1-one and their anticancer activity
- Authors: Mohamed S.F.1, Hosni H.M.2, Amr A.E.1,3, Abdalla M.M.4
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Affiliations:
- Applied Organic Chemistry Department
- Pesticide Chemistry Department
- Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC)
- Research Unit, Saco Pharm. Co.
- Issue: Vol 86, No 3 (2016)
- Pages: 672-680
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/214351
- DOI: https://doi.org/10.1134/S1070363216030269
- ID: 214351
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Abstract
A series of novel substituted pyridine derivatives have been synthesized via the reaction of 3-indole carboxaldehyde with 3-aminoacetophenone. The products structures have been elucidated from elemental analysis as well as IR, 1H NMR, 13C NMR, and MS spectroscopy data. All the synthesized compounds have shown anticancer activity against HEPG2 and MCF-7 in vitro; some of them have exhibited the in vivo activity.
About the authors
S. F. Mohamed
Applied Organic Chemistry Department
Author for correspondence.
Email: drsalwafahim@yahoo.com
Egypt, Cairo, Dokki, 12622
H. M. Hosni
Pesticide Chemistry Department
Email: drsalwafahim@yahoo.com
Egypt, Dokki, Cairo, 12622
A. E. Amr
Applied Organic Chemistry Department; Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC)
Email: drsalwafahim@yahoo.com
Egypt, Cairo, Dokki, 12622; Riyadh, 11451
M. M. Abdalla
Research Unit, Saco Pharm. Co.
Email: drsalwafahim@yahoo.com
Egypt, 6 October City, Cairo, 11632
