Synthesis of novel substituted pyridines from 1-(3-aminophenyl)-3-(1H-indol-3-yl)prop-2-en-1-one and their anticancer activity
- Авторы: Mohamed S.1, Hosni H.2, Amr A.1,3, Abdalla M.4
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Учреждения:
- Applied Organic Chemistry Department
- Pesticide Chemistry Department
- Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC)
- Research Unit, Saco Pharm. Co.
- Выпуск: Том 86, № 3 (2016)
- Страницы: 672-680
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/214351
- DOI: https://doi.org/10.1134/S1070363216030269
- ID: 214351
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Аннотация
A series of novel substituted pyridine derivatives have been synthesized via the reaction of 3-indole carboxaldehyde with 3-aminoacetophenone. The products structures have been elucidated from elemental analysis as well as IR, 1H NMR, 13C NMR, and MS spectroscopy data. All the synthesized compounds have shown anticancer activity against HEPG2 and MCF-7 in vitro; some of them have exhibited the in vivo activity.
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Об авторах
S. Mohamed
Applied Organic Chemistry Department
Автор, ответственный за переписку.
Email: drsalwafahim@yahoo.com
Египет, Cairo, Dokki, 12622
H. Hosni
Pesticide Chemistry Department
Email: drsalwafahim@yahoo.com
Египет, Dokki, Cairo, 12622
A. Amr
Applied Organic Chemistry Department; Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC)
Email: drsalwafahim@yahoo.com
Египет, Cairo, Dokki, 12622; Riyadh, 11451
M. Abdalla
Research Unit, Saco Pharm. Co.
Email: drsalwafahim@yahoo.com
Египет, 6 October City, Cairo, 11632