Synthesis of novel substituted pyridines from 1-(3-aminophenyl)-3-(1H-indol-3-yl)prop-2-en-1-one and their anticancer activity
- 作者: Mohamed S.1, Hosni H.2, Amr A.1,3, Abdalla M.4
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隶属关系:
- Applied Organic Chemistry Department
- Pesticide Chemistry Department
- Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC)
- Research Unit, Saco Pharm. Co.
- 期: 卷 86, 编号 3 (2016)
- 页面: 672-680
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/214351
- DOI: https://doi.org/10.1134/S1070363216030269
- ID: 214351
如何引用文章
详细
A series of novel substituted pyridine derivatives have been synthesized via the reaction of 3-indole carboxaldehyde with 3-aminoacetophenone. The products structures have been elucidated from elemental analysis as well as IR, 1H NMR, 13C NMR, and MS spectroscopy data. All the synthesized compounds have shown anticancer activity against HEPG2 and MCF-7 in vitro; some of them have exhibited the in vivo activity.
作者简介
S. Mohamed
Applied Organic Chemistry Department
编辑信件的主要联系方式.
Email: drsalwafahim@yahoo.com
埃及, Cairo, Dokki, 12622
H. Hosni
Pesticide Chemistry Department
Email: drsalwafahim@yahoo.com
埃及, Dokki, Cairo, 12622
A. Amr
Applied Organic Chemistry Department; Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC)
Email: drsalwafahim@yahoo.com
埃及, Cairo, Dokki, 12622; Riyadh, 11451
M. Abdalla
Research Unit, Saco Pharm. Co.
Email: drsalwafahim@yahoo.com
埃及, 6 October City, Cairo, 11632