Hepatoprotective Activity of Betulin and Dipterocarpol Derivatives
- 作者: Kazakova O.1, Smirnova I.1, Medvedeva N.1, Lopatina T.1, Chudov I.2, Sharipov A.2, Ziganshin A.2, Thao T.3
-
隶属关系:
- Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
- Bashkir State Agrarian University
- Institute of Chemistry, Vietnam Academy of Science and Technology
- 期: 卷 45, 编号 6 (2019)
- 页面: 558-565
- 栏目: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229254
- DOI: https://doi.org/10.1134/S1068162019050030
- ID: 229254
如何引用文章
详细
The regioselective synthesis of betulin 3,28-bis- and 28-monoacylates (nicotinate and isonicotinates) as well as of 3β-hemisuccinyl dipterocarpol was carried out using the dicyclohexylcarbodiimide method. The morphological and biochemical blood tests on a model of CCl4-induced rat hepatitis showed that the activities of the betulin bisacylates 3β,28-bis-О-nicotinate and 3β,28-bis-О-isonicotinate were higher than that of monoacylate 28-О-isonicotinate. 3β-Hydroxydipterocarpol was found to be the most active among triterpenoids of the dammarane type.
作者简介
O. Kazakova
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: obf@anrb.ru
俄罗斯联邦, Ufa, 450054
I. Smirnova
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
Email: obf@anrb.ru
俄罗斯联邦, Ufa, 450054
N. Medvedeva
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
Email: obf@anrb.ru
俄罗斯联邦, Ufa, 450054
T. Lopatina
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
Email: obf@anrb.ru
俄罗斯联邦, Ufa, 450054
I. Chudov
Bashkir State Agrarian University
Email: obf@anrb.ru
俄罗斯联邦, Ufa, 450001
A. Sharipov
Bashkir State Agrarian University
Email: obf@anrb.ru
俄罗斯联邦, Ufa, 450001
A. Ziganshin
Bashkir State Agrarian University
Email: obf@anrb.ru
俄罗斯联邦, Ufa, 450001
Tran Thao
Institute of Chemistry, Vietnam Academy of Science and Technology
Email: obf@anrb.ru
越南, Hanoi, 100000