Hepatoprotective Activity of Betulin and Dipterocarpol Derivatives

O. B. Kazakova; I. E. Smirnova; N. I. Medvedeva; T. V. Lopatina; I. V. Chudov; A. R. Sharipov; A. S. Ziganshin; Tran Thi Phuong Thao

doi:10.1134/S1068162019050030

Hepatoprotective Activity of Betulin and Dipterocarpol Derivatives

Authors: Kazakova O.B.¹, Smirnova I.E.¹, Medvedeva N.I.¹, Lopatina T.V.¹, Chudov I.V.², Sharipov A.R.², Ziganshin A.S.², Thao T.T.³
Affiliations:
1. Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
2. Bashkir State Agrarian University
3. Institute of Chemistry, Vietnam Academy of Science and Technology
Issue: Vol 45, No 6 (2019)
Pages: 558-565
Section: Article
URL: https://journals.rcsi.science/1068-1620/article/view/229254
DOI: https://doi.org/10.1134/S1068162019050030
ID: 229254

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Abstract

The regioselective synthesis of betulin 3,28-bis- and 28-monoacylates (nicotinate and isonicotinates) as well as of 3β-hemisuccinyl dipterocarpol was carried out using the dicyclohexylcarbodiimide method. The morphological and biochemical blood tests on a model of CCl₄-induced rat hepatitis showed that the activities of the betulin bisacylates 3β,28-bis-О-nicotinate and 3β,28-bis-О-isonicotinate were higher than that of monoacylate 28-О-isonicotinate. 3β-Hydroxydipterocarpol was found to be the most active among triterpenoids of the dammarane type.

Keywords

acylation, betulin, dammaranes, dipterocarpol, hepatoprotective activity, lupanes, triterpenoids

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Hepatoprotective Activity of Betulin and Dipterocarpol Derivatives

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Abstract

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About the authors

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