Hepatoprotective Activity of Betulin and Dipterocarpol Derivatives
- Authors: Kazakova O.B.1, Smirnova I.E.1, Medvedeva N.I.1, Lopatina T.V.1, Chudov I.V.2, Sharipov A.R.2, Ziganshin A.S.2, Thao T.T.3
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Affiliations:
- Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
- Bashkir State Agrarian University
- Institute of Chemistry, Vietnam Academy of Science and Technology
- Issue: Vol 45, No 6 (2019)
- Pages: 558-565
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229254
- DOI: https://doi.org/10.1134/S1068162019050030
- ID: 229254
Cite item
Abstract
The regioselective synthesis of betulin 3,28-bis- and 28-monoacylates (nicotinate and isonicotinates) as well as of 3β-hemisuccinyl dipterocarpol was carried out using the dicyclohexylcarbodiimide method. The morphological and biochemical blood tests on a model of CCl4-induced rat hepatitis showed that the activities of the betulin bisacylates 3β,28-bis-О-nicotinate and 3β,28-bis-О-isonicotinate were higher than that of monoacylate 28-О-isonicotinate. 3β-Hydroxydipterocarpol was found to be the most active among triterpenoids of the dammarane type.
Keywords
About the authors
O. B. Kazakova
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
Author for correspondence.
Email: obf@anrb.ru
Russian Federation, Ufa, 450054
I. E. Smirnova
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
Email: obf@anrb.ru
Russian Federation, Ufa, 450054
N. I. Medvedeva
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
Email: obf@anrb.ru
Russian Federation, Ufa, 450054
T. V. Lopatina
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
Email: obf@anrb.ru
Russian Federation, Ufa, 450054
I. V. Chudov
Bashkir State Agrarian University
Email: obf@anrb.ru
Russian Federation, Ufa, 450001
A. R. Sharipov
Bashkir State Agrarian University
Email: obf@anrb.ru
Russian Federation, Ufa, 450001
A. S. Ziganshin
Bashkir State Agrarian University
Email: obf@anrb.ru
Russian Federation, Ufa, 450001
Tran Thi Phuong Thao
Institute of Chemistry, Vietnam Academy of Science and Technology
Email: obf@anrb.ru
Viet Nam, Hanoi, 100000