Hepatoprotective Activity of Betulin and Dipterocarpol Derivatives
- Autores: Kazakova O.1, Smirnova I.1, Medvedeva N.1, Lopatina T.1, Chudov I.2, Sharipov A.2, Ziganshin A.2, Thao T.3
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Afiliações:
- Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
- Bashkir State Agrarian University
- Institute of Chemistry, Vietnam Academy of Science and Technology
- Edição: Volume 45, Nº 6 (2019)
- Páginas: 558-565
- Seção: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229254
- DOI: https://doi.org/10.1134/S1068162019050030
- ID: 229254
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Resumo
The regioselective synthesis of betulin 3,28-bis- and 28-monoacylates (nicotinate and isonicotinates) as well as of 3β-hemisuccinyl dipterocarpol was carried out using the dicyclohexylcarbodiimide method. The morphological and biochemical blood tests on a model of CCl4-induced rat hepatitis showed that the activities of the betulin bisacylates 3β,28-bis-О-nicotinate and 3β,28-bis-О-isonicotinate were higher than that of monoacylate 28-О-isonicotinate. 3β-Hydroxydipterocarpol was found to be the most active among triterpenoids of the dammarane type.
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Sobre autores
O. Kazakova
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
Autor responsável pela correspondência
Email: obf@anrb.ru
Rússia, Ufa, 450054
I. Smirnova
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
Email: obf@anrb.ru
Rússia, Ufa, 450054
N. Medvedeva
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
Email: obf@anrb.ru
Rússia, Ufa, 450054
T. Lopatina
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
Email: obf@anrb.ru
Rússia, Ufa, 450054
I. Chudov
Bashkir State Agrarian University
Email: obf@anrb.ru
Rússia, Ufa, 450001
A. Sharipov
Bashkir State Agrarian University
Email: obf@anrb.ru
Rússia, Ufa, 450001
A. Ziganshin
Bashkir State Agrarian University
Email: obf@anrb.ru
Rússia, Ufa, 450001
Tran Thao
Institute of Chemistry, Vietnam Academy of Science and Technology
Email: obf@anrb.ru
Vietnã, Hanoi, 100000