Synthesis of New 1,4-Diarylimidazoles and 1-Aryl-4-(5-Nitrofuran-2-il)imidazoles and Study of Their Anti-Infective Activity

Resumo

Using 1-R-benzimidazoles and ω-bromoacetophenones or 2-bromoacetyl-5-nitrofuran, the corresponding quaternary 1-R-3-acylmethylbenzimidazolium salts have been obtained which transformed under the action of ammonium acetate into the previously undescribed 1,4-diarylimidazoles and 1-aryl-4- (5-nitrofuran-2-il)imidazoles. The antiprotozoal, fungistatic, and antimicrobial activities of these compounds have been tested.