Synthesis of New 1,4-Diarylimidazoles and 1-Aryl-4-(5-Nitrofuran-2-il)imidazoles and Study of Their Anti-Infective Activity

T. A. Kuzmenko; L. N. Divaeva; A. S. Morkovnik; Yu. V. Koshchienko; A. A. Zubenko; Yu. D. Drobin; L. N. Fetisov; A. N. Bodryakov

doi:10.1134/S1068162018050096

Synthesis of New 1,4-Diarylimidazoles and 1-Aryl-4-(5-Nitrofuran-2-il)imidazoles and Study of Their Anti-Infective Activity

Авторлар: Kuzmenko T.¹, Divaeva L.¹, Morkovnik A.¹, Koshchienko Y.¹, Zubenko A.², Drobin Y.², Fetisov L.², Bodryakov A.²
Мекемелер:
1. Research Institute of Physical and Organic Chemistry
2. North Caucasus Zonal Veterinary Research Institute
Шығарылым: Том 44, № 6 (2018)
Беттер: 795-800
Бөлім: Article
URL: https://journals.rcsi.science/1068-1620/article/view/229075
DOI: https://doi.org/10.1134/S1068162018050096
ID: 229075

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Аннотация

Using 1-R-benzimidazoles and ω-bromoacetophenones or 2-bromoacetyl-5-nitrofuran, the corresponding quaternary 1-R-3-acylmethylbenzimidazolium salts have been obtained which transformed under the action of ammonium acetate into the previously undescribed 1,4-diarylimidazoles and 1-aryl-4- (5-nitrofuran-2-il)imidazoles. The antiprotozoal, fungistatic, and antimicrobial activities of these compounds have been tested.