Synthesis of New 1,4-Diarylimidazoles and 1-Aryl-4-(5-Nitrofuran-2-il)imidazoles and Study of Their Anti-Infective Activity


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Using 1-R-benzimidazoles and ω-bromoacetophenones or 2-bromoacetyl-5-nitrofuran, the corresponding quaternary 1-R-3-acylmethylbenzimidazolium salts have been obtained which transformed under the action of ammonium acetate into the previously undescribed 1,4-diarylimidazoles and 1-aryl-4- (5-nitrofuran-2-il)imidazoles. The antiprotozoal, fungistatic, and antimicrobial activities of these compounds have been tested.

作者简介

T. Kuzmenko

Research Institute of Physical and Organic Chemistry

Email: divaevaln@mail.ru
俄罗斯联邦, Rostov-on-Don, 344090

L. Divaeva

Research Institute of Physical and Organic Chemistry

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Email: divaevaln@mail.ru
俄罗斯联邦, Rostov-on-Don, 344090

A. Morkovnik

Research Institute of Physical and Organic Chemistry

Email: divaevaln@mail.ru
俄罗斯联邦, Rostov-on-Don, 344090

Yu. Koshchienko

Research Institute of Physical and Organic Chemistry

Email: divaevaln@mail.ru
俄罗斯联邦, Rostov-on-Don, 344090

A. Zubenko

North Caucasus Zonal Veterinary Research Institute

Email: divaevaln@mail.ru
俄罗斯联邦, Novocherkassk, 346421

Yu. Drobin

North Caucasus Zonal Veterinary Research Institute

Email: divaevaln@mail.ru
俄罗斯联邦, Novocherkassk, 346421

L. Fetisov

North Caucasus Zonal Veterinary Research Institute

Email: divaevaln@mail.ru
俄罗斯联邦, Novocherkassk, 346421

A. Bodryakov

North Caucasus Zonal Veterinary Research Institute

Email: divaevaln@mail.ru
俄罗斯联邦, Novocherkassk, 346421

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