Synthesis of New 1,4-Diarylimidazoles and 1-Aryl-4-(5-Nitrofuran-2-il)imidazoles and Study of Their Anti-Infective Activity

T. A. Kuzmenko; L. N. Divaeva; A. S. Morkovnik; Yu. V. Koshchienko; A. A. Zubenko; Yu. D. Drobin; L. N. Fetisov; A. N. Bodryakov

doi:10.1134/S1068162018050096

Synthesis of New 1,4-Diarylimidazoles and 1-Aryl-4-(5-Nitrofuran-2-il)imidazoles and Study of Their Anti-Infective Activity

Authors: Kuzmenko T.A.¹, Divaeva L.N.¹, Morkovnik A.S.¹, Koshchienko Y.V.¹, Zubenko A.A.², Drobin Y.D.², Fetisov L.N.², Bodryakov A.N.²
Affiliations:
1. Research Institute of Physical and Organic Chemistry
2. North Caucasus Zonal Veterinary Research Institute
Issue: Vol 44, No 6 (2018)
Pages: 795-800
Section: Article
URL: https://journals.rcsi.science/1068-1620/article/view/229075
DOI: https://doi.org/10.1134/S1068162018050096
ID: 229075

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Abstract

Using 1-R-benzimidazoles and ω-bromoacetophenones or 2-bromoacetyl-5-nitrofuran, the corresponding quaternary 1-R-3-acylmethylbenzimidazolium salts have been obtained which transformed under the action of ammonium acetate into the previously undescribed 1,4-diarylimidazoles and 1-aryl-4- (5-nitrofuran-2-il)imidazoles. The antiprotozoal, fungistatic, and antimicrobial activities of these compounds have been tested.