Мақаланы E-mail арқылы жіберу New Ionic Conjugates Based on α-Tocopheryl Succinate as Potential Cytotoxic Agents
- Авторлар: Frolova T.1,2,3, Sharapov S.2,3, Sinitsyna O.2,3, Tolstikova T.1,3, Grigoriev I.1,4, Morozov S.1,3, Yushkova Y.1
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Мекемелер:
- Novosibirsk Institute of Organic Chemistry, Siberian Branch
- Institute of Cytology and Genetics, Siberian Branch
- Novosibirsk State University
- Meshalkin State Research Institute of Circulation Pathology
- Шығарылым: Том 44, № 3 (2018)
- Беттер: 330-336
- Бөлім: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228935
- DOI: https://doi.org/10.1134/S1068162018030068
- ID: 228935
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Five new ionic conjugates based on α-tocopheryl succinate were synthesized, including amino- TEMPO, cytisine, convolvin, amantadine, and rimantadine as functional groups. Using bacterial test systems, the safety of the compounds obtained was shown, and antioxidant properties were studied. Investigation of the cytotoxic properties of synthesized conjugates with a chromane skeleton revealed their selectivity to the MCF7 breast cancer line, the effect was most pronounced for derivatives with amino-TEMPO and rimantadine fragments.
Авторлар туралы
T. Frolova
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
Хат алмасуға жауапты Автор.
Email: frolova@nioch.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090; Novosibirsk, 630090
S. Sharapov
Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090
O. Sinitsyna
Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090
T. Tolstikova
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090
I. Grigoriev
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Meshalkin State Research Institute of Circulation Pathology
Email: frolova@nioch.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk
S. Morozov
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
Ресей, Novosibirsk, 630090; Novosibirsk, 630090
Y. Yushkova
Novosibirsk Institute of Organic Chemistry, Siberian Branch
Email: frolova@nioch.nsc.ru
Ресей, Novosibirsk, 630090
