New Ionic Conjugates Based on α-Tocopheryl Succinate as Potential Cytotoxic Agents
- 作者: Frolova T.1,2,3, Sharapov S.2,3, Sinitsyna O.2,3, Tolstikova T.1,3, Grigoriev I.1,4, Morozov S.1,3, Yushkova Y.1
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隶属关系:
- Novosibirsk Institute of Organic Chemistry, Siberian Branch
- Institute of Cytology and Genetics, Siberian Branch
- Novosibirsk State University
- Meshalkin State Research Institute of Circulation Pathology
- 期: 卷 44, 编号 3 (2018)
- 页面: 330-336
- 栏目: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228935
- DOI: https://doi.org/10.1134/S1068162018030068
- ID: 228935
如何引用文章
详细
Five new ionic conjugates based on α-tocopheryl succinate were synthesized, including amino- TEMPO, cytisine, convolvin, amantadine, and rimantadine as functional groups. Using bacterial test systems, the safety of the compounds obtained was shown, and antioxidant properties were studied. Investigation of the cytotoxic properties of synthesized conjugates with a chromane skeleton revealed their selectivity to the MCF7 breast cancer line, the effect was most pronounced for derivatives with amino-TEMPO and rimantadine fragments.
作者简介
T. Frolova
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
编辑信件的主要联系方式.
Email: frolova@nioch.nsc.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk, 630090; Novosibirsk, 630090
S. Sharapov
Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk, 630090
O. Sinitsyna
Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk, 630090
T. Tolstikova
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk, 630090
I. Grigoriev
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Meshalkin State Research Institute of Circulation Pathology
Email: frolova@nioch.nsc.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk
S. Morozov
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
俄罗斯联邦, Novosibirsk, 630090; Novosibirsk, 630090
Y. Yushkova
Novosibirsk Institute of Organic Chemistry, Siberian Branch
Email: frolova@nioch.nsc.ru
俄罗斯联邦, Novosibirsk, 630090