Email this article New Ionic Conjugates Based on α-Tocopheryl Succinate as Potential Cytotoxic Agents
- Authors: Frolova T.S.1,2,3, Sharapov S.Z.2,3, Sinitsyna O.I.2,3, Tolstikova T.G.1,3, Grigoriev I.A.1,4, Morozov S.V.1,3, Yushkova Y.V.1
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Affiliations:
- Novosibirsk Institute of Organic Chemistry, Siberian Branch
- Institute of Cytology and Genetics, Siberian Branch
- Novosibirsk State University
- Meshalkin State Research Institute of Circulation Pathology
- Issue: Vol 44, No 3 (2018)
- Pages: 330-336
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228935
- DOI: https://doi.org/10.1134/S1068162018030068
- ID: 228935
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Abstract
Five new ionic conjugates based on α-tocopheryl succinate were synthesized, including amino- TEMPO, cytisine, convolvin, amantadine, and rimantadine as functional groups. Using bacterial test systems, the safety of the compounds obtained was shown, and antioxidant properties were studied. Investigation of the cytotoxic properties of synthesized conjugates with a chromane skeleton revealed their selectivity to the MCF7 breast cancer line, the effect was most pronounced for derivatives with amino-TEMPO and rimantadine fragments.
About the authors
T. S. Frolova
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
Author for correspondence.
Email: frolova@nioch.nsc.ru
Russian Federation, Novosibirsk, 630090; Novosibirsk, 630090; Novosibirsk, 630090
S. Z. Sharapov
Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
Russian Federation, Novosibirsk, 630090; Novosibirsk, 630090
O. I. Sinitsyna
Institute of Cytology and Genetics, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
Russian Federation, Novosibirsk, 630090; Novosibirsk, 630090
T. G. Tolstikova
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
Russian Federation, Novosibirsk, 630090; Novosibirsk, 630090
I. A. Grigoriev
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Meshalkin State Research Institute of Circulation Pathology
Email: frolova@nioch.nsc.ru
Russian Federation, Novosibirsk, 630090; Novosibirsk
S. V. Morozov
Novosibirsk Institute of Organic Chemistry, Siberian Branch; Novosibirsk State University
Email: frolova@nioch.nsc.ru
Russian Federation, Novosibirsk, 630090; Novosibirsk, 630090
Y. V. Yushkova
Novosibirsk Institute of Organic Chemistry, Siberian Branch
Email: frolova@nioch.nsc.ru
Russian Federation, Novosibirsk, 630090
