The Synthesis and Selective Cytotoxicity of New Mannich Bases, Derivatives of 19- and 28-Alkynyltriterpenoids
- Авторы: Khusnutdinova E.F.1, Apryshko G.N.2, Petrova A.V.3, Kukovinets O.S.3, Kazakova O.B.1
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Учреждения:
- Ufa Institute of Chemistry
- N.N. Blokhin Russian Cancer Research Center
- Bashkir State University
- Выпуск: Том 44, № 1 (2018)
- Страницы: 123-127
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228838
- DOI: https://doi.org/10.1134/S1068162018010090
- ID: 228838
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Аннотация
New propargylamines were synthesized in 72–75% yields by the interaction of 19-alkynylbetulin and 28-O-propargyl glycinamide of oleanolic acid with N-methylpiperazine under the Mannich reaction conditions. 19-[1-Methyl-4-prop-2-yn-1-yl-piperazine]-20,29,30-trinorbetulin was shown to manifest anticancer activity against one line of leukemia cells and two lines of colon cancer cells, whereas the growth of leukemia cells SR in the presence of 4-(4-methylpiperazin-1-yl)but-2-yn-1-yl-N-(3-hydroxy-28-oxoolean-12-en-28-yl)glycinate was 8%.
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Об авторах
E. Khusnutdinova
Ufa Institute of Chemistry
Автор, ответственный за переписку.
Email: ElmaH@inbox.ru
Россия, Ufa, 450054
G. Apryshko
N.N. Blokhin Russian Cancer Research Center
Email: ElmaH@inbox.ru
Россия, Moscow, 115478
A. Petrova
Bashkir State University
Email: ElmaH@inbox.ru
Россия, Ufa, 450076
O. Kukovinets
Bashkir State University
Email: ElmaH@inbox.ru
Россия, Ufa, 450076
O. Kazakova
Ufa Institute of Chemistry
Email: ElmaH@inbox.ru
Россия, Ufa, 450054
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