The Synthesis and Selective Cytotoxicity of New Mannich Bases, Derivatives of 19- and 28-Alkynyltriterpenoids
- Authors: Khusnutdinova E.F.1, Apryshko G.N.2, Petrova A.V.3, Kukovinets O.S.3, Kazakova O.B.1
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Affiliations:
- Ufa Institute of Chemistry
- N.N. Blokhin Russian Cancer Research Center
- Bashkir State University
- Issue: Vol 44, No 1 (2018)
- Pages: 123-127
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228838
- DOI: https://doi.org/10.1134/S1068162018010090
- ID: 228838
Cite item
Abstract
New propargylamines were synthesized in 72–75% yields by the interaction of 19-alkynylbetulin and 28-O-propargyl glycinamide of oleanolic acid with N-methylpiperazine under the Mannich reaction conditions. 19-[1-Methyl-4-prop-2-yn-1-yl-piperazine]-20,29,30-trinorbetulin was shown to manifest anticancer activity against one line of leukemia cells and two lines of colon cancer cells, whereas the growth of leukemia cells SR in the presence of 4-(4-methylpiperazin-1-yl)but-2-yn-1-yl-N-(3-hydroxy-28-oxoolean-12-en-28-yl)glycinate was 8%.
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About the authors
E. F. Khusnutdinova
Ufa Institute of Chemistry
Author for correspondence.
Email: ElmaH@inbox.ru
Russian Federation, Ufa, 450054
G. N. Apryshko
N.N. Blokhin Russian Cancer Research Center
Email: ElmaH@inbox.ru
Russian Federation, Moscow, 115478
A. V. Petrova
Bashkir State University
Email: ElmaH@inbox.ru
Russian Federation, Ufa, 450076
O. S. Kukovinets
Bashkir State University
Email: ElmaH@inbox.ru
Russian Federation, Ufa, 450076
O. B. Kazakova
Ufa Institute of Chemistry
Email: ElmaH@inbox.ru
Russian Federation, Ufa, 450054