The Synthesis and Selective Cytotoxicity of New Mannich Bases, Derivatives of 19- and 28-Alkynyltriterpenoids
- 作者: Khusnutdinova E.1, Apryshko G.2, Petrova A.3, Kukovinets O.3, Kazakova O.1
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隶属关系:
- Ufa Institute of Chemistry
- N.N. Blokhin Russian Cancer Research Center
- Bashkir State University
- 期: 卷 44, 编号 1 (2018)
- 页面: 123-127
- 栏目: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228838
- DOI: https://doi.org/10.1134/S1068162018010090
- ID: 228838
如何引用文章
详细
New propargylamines were synthesized in 72–75% yields by the interaction of 19-alkynylbetulin and 28-O-propargyl glycinamide of oleanolic acid with N-methylpiperazine under the Mannich reaction conditions. 19-[1-Methyl-4-prop-2-yn-1-yl-piperazine]-20,29,30-trinorbetulin was shown to manifest anticancer activity against one line of leukemia cells and two lines of colon cancer cells, whereas the growth of leukemia cells SR in the presence of 4-(4-methylpiperazin-1-yl)but-2-yn-1-yl-N-(3-hydroxy-28-oxoolean-12-en-28-yl)glycinate was 8%.
作者简介
E. Khusnutdinova
Ufa Institute of Chemistry
编辑信件的主要联系方式.
Email: ElmaH@inbox.ru
俄罗斯联邦, Ufa, 450054
G. Apryshko
N.N. Blokhin Russian Cancer Research Center
Email: ElmaH@inbox.ru
俄罗斯联邦, Moscow, 115478
A. Petrova
Bashkir State University
Email: ElmaH@inbox.ru
俄罗斯联邦, Ufa, 450076
O. Kukovinets
Bashkir State University
Email: ElmaH@inbox.ru
俄罗斯联邦, Ufa, 450076
O. Kazakova
Ufa Institute of Chemistry
Email: ElmaH@inbox.ru
俄罗斯联邦, Ufa, 450054