The Synthesis and Selective Cytotoxicity of New Mannich Bases, Derivatives of 19- and 28-Alkynyltriterpenoids
- Autores: Khusnutdinova E.1, Apryshko G.2, Petrova A.3, Kukovinets O.3, Kazakova O.1
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Afiliações:
- Ufa Institute of Chemistry
- N.N. Blokhin Russian Cancer Research Center
- Bashkir State University
- Edição: Volume 44, Nº 1 (2018)
- Páginas: 123-127
- Seção: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228838
- DOI: https://doi.org/10.1134/S1068162018010090
- ID: 228838
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Resumo
New propargylamines were synthesized in 72–75% yields by the interaction of 19-alkynylbetulin and 28-O-propargyl glycinamide of oleanolic acid with N-methylpiperazine under the Mannich reaction conditions. 19-[1-Methyl-4-prop-2-yn-1-yl-piperazine]-20,29,30-trinorbetulin was shown to manifest anticancer activity against one line of leukemia cells and two lines of colon cancer cells, whereas the growth of leukemia cells SR in the presence of 4-(4-methylpiperazin-1-yl)but-2-yn-1-yl-N-(3-hydroxy-28-oxoolean-12-en-28-yl)glycinate was 8%.
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Sobre autores
E. Khusnutdinova
Ufa Institute of Chemistry
Autor responsável pela correspondência
Email: ElmaH@inbox.ru
Rússia, Ufa, 450054
G. Apryshko
N.N. Blokhin Russian Cancer Research Center
Email: ElmaH@inbox.ru
Rússia, Moscow, 115478
A. Petrova
Bashkir State University
Email: ElmaH@inbox.ru
Rússia, Ufa, 450076
O. Kukovinets
Bashkir State University
Email: ElmaH@inbox.ru
Rússia, Ufa, 450076
O. Kazakova
Ufa Institute of Chemistry
Email: ElmaH@inbox.ru
Rússia, Ufa, 450054