Enviar artigo por via de e-mail Study of the Carbohydrate Specificity of Antibodies Against Aspergillus fumigatus Using the Library of Synthetic Mycoantigens
- Autores: Krylov V.B.1, Petruk M.I.1, Grigoryev I.V.2, Lebedin Y.S.2, Glushko N.I.3, Khaldeeva E.V.3, Argunov D.A.1, Khatuntseva E.A.1, Toplishek M.V.1, Komarova B.S.1, Karelin A.A.1, Yudina O.N.1, Menshov V.M.1, Yashunskii D.V.1, Tsvetkov Y.E.1, Nifantiev N.E.1
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Afiliações:
- Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
- XEMA Company Limited
- Kazan Scientific Research Institute of Epidemiology and Microbiology
- Edição: Volume 44, Nº 1 (2018)
- Páginas: 80-89
- Seção: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228804
- DOI: https://doi.org/10.1134/S1068162017060073
- ID: 228804
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Resumo
The carbohydrate specificity of antibodies obtained by immunizing laboratory animals with immunogens prepared from the Aspergillus fumigatus cell wall was analyzed using the library of biotinylated synthetic oligosaccharides. It has been shown that the main part of antipolysaccharide antibodies recognizes galactomannan in the studied immunogens with preference to its fragments containing more than two β-(1→5)-linked galactofuranosyl units. The data obtained can form the basis for the development of enzyme immunoassay for the detection of this dangerous fungal pathogen.
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Sobre autores
V. Krylov
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Rússia, Moscow, 119991
M. Petruk
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Rússia, Moscow, 119991
I. Grigoryev
XEMA Company Limited
Email: nen@ioc.ac.ru
Rússia, Moscow, 105264
Y. Lebedin
XEMA Company Limited
Email: nen@ioc.ac.ru
Rússia, Moscow, 105264
N. Glushko
Kazan Scientific Research Institute of Epidemiology and Microbiology
Email: nen@ioc.ac.ru
Rússia, Kazan, 420015
E. Khaldeeva
Kazan Scientific Research Institute of Epidemiology and Microbiology
Email: nen@ioc.ac.ru
Rússia, Kazan, 420015
D. Argunov
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Rússia, Moscow, 119991
E. Khatuntseva
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Rússia, Moscow, 119991
M. Toplishek
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Rússia, Moscow, 119991
B. Komarova
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Rússia, Moscow, 119991
A. Karelin
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Rússia, Moscow, 119991
O. Yudina
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Rússia, Moscow, 119991
V. Menshov
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Rússia, Moscow, 119991
D. Yashunskii
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Rússia, Moscow, 119991
Y. Tsvetkov
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Rússia, Moscow, 119991
N. Nifantiev
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Autor responsável pela correspondência
Email: nen@ioc.ac.ru
Rússia, Moscow, 119991
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