Study of the Carbohydrate Specificity of Antibodies Against Aspergillus fumigatus Using the Library of Synthetic Mycoantigens
- Авторы: Krylov V.B.1, Petruk M.I.1, Grigoryev I.V.2, Lebedin Y.S.2, Glushko N.I.3, Khaldeeva E.V.3, Argunov D.A.1, Khatuntseva E.A.1, Toplishek M.V.1, Komarova B.S.1, Karelin A.A.1, Yudina O.N.1, Menshov V.M.1, Yashunskii D.V.1, Tsvetkov Y.E.1, Nifantiev N.E.1
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Учреждения:
- Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
- XEMA Company Limited
- Kazan Scientific Research Institute of Epidemiology and Microbiology
- Выпуск: Том 44, № 1 (2018)
- Страницы: 80-89
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228804
- DOI: https://doi.org/10.1134/S1068162017060073
- ID: 228804
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Аннотация
The carbohydrate specificity of antibodies obtained by immunizing laboratory animals with immunogens prepared from the Aspergillus fumigatus cell wall was analyzed using the library of biotinylated synthetic oligosaccharides. It has been shown that the main part of antipolysaccharide antibodies recognizes galactomannan in the studied immunogens with preference to its fragments containing more than two β-(1→5)-linked galactofuranosyl units. The data obtained can form the basis for the development of enzyme immunoassay for the detection of this dangerous fungal pathogen.
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Об авторах
V. Krylov
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Россия, Moscow, 119991
M. Petruk
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Россия, Moscow, 119991
I. Grigoryev
XEMA Company Limited
Email: nen@ioc.ac.ru
Россия, Moscow, 105264
Y. Lebedin
XEMA Company Limited
Email: nen@ioc.ac.ru
Россия, Moscow, 105264
N. Glushko
Kazan Scientific Research Institute of Epidemiology and Microbiology
Email: nen@ioc.ac.ru
Россия, Kazan, 420015
E. Khaldeeva
Kazan Scientific Research Institute of Epidemiology and Microbiology
Email: nen@ioc.ac.ru
Россия, Kazan, 420015
D. Argunov
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Россия, Moscow, 119991
E. Khatuntseva
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Россия, Moscow, 119991
M. Toplishek
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Россия, Moscow, 119991
B. Komarova
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Россия, Moscow, 119991
A. Karelin
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Россия, Moscow, 119991
O. Yudina
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Россия, Moscow, 119991
V. Menshov
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Россия, Moscow, 119991
D. Yashunskii
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Россия, Moscow, 119991
Y. Tsvetkov
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
Россия, Moscow, 119991
N. Nifantiev
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Автор, ответственный за переписку.
Email: nen@ioc.ac.ru
Россия, Moscow, 119991
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