Study of the Carbohydrate Specificity of Antibodies Against Aspergillus fumigatus Using the Library of Synthetic Mycoantigens


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The carbohydrate specificity of antibodies obtained by immunizing laboratory animals with immunogens prepared from the Aspergillus fumigatus cell wall was analyzed using the library of biotinylated synthetic oligosaccharides. It has been shown that the main part of antipolysaccharide antibodies recognizes galactomannan in the studied immunogens with preference to its fragments containing more than two β-(1→5)-linked galactofuranosyl units. The data obtained can form the basis for the development of enzyme immunoassay for the detection of this dangerous fungal pathogen.

作者简介

V. Krylov

Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry

Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991

M. Petruk

Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry

Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991

I. Grigoryev

XEMA Company Limited

Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 105264

Y. Lebedin

XEMA Company Limited

Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 105264

N. Glushko

Kazan Scientific Research Institute of Epidemiology and Microbiology

Email: nen@ioc.ac.ru
俄罗斯联邦, Kazan, 420015

E. Khaldeeva

Kazan Scientific Research Institute of Epidemiology and Microbiology

Email: nen@ioc.ac.ru
俄罗斯联邦, Kazan, 420015

D. Argunov

Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry

Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991

E. Khatuntseva

Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry

Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991

M. Toplishek

Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry

Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991

B. Komarova

Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry

Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991

A. Karelin

Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry

Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991

O. Yudina

Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry

Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991

V. Menshov

Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry

Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991

D. Yashunskii

Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry

Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991

Y. Tsvetkov

Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry

Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991

N. Nifantiev

Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry

编辑信件的主要联系方式.
Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991

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