Study of the Carbohydrate Specificity of Antibodies Against Aspergillus fumigatus Using the Library of Synthetic Mycoantigens
- 作者: Krylov V.B.1, Petruk M.I.1, Grigoryev I.V.2, Lebedin Y.S.2, Glushko N.I.3, Khaldeeva E.V.3, Argunov D.A.1, Khatuntseva E.A.1, Toplishek M.V.1, Komarova B.S.1, Karelin A.A.1, Yudina O.N.1, Menshov V.M.1, Yashunskii D.V.1, Tsvetkov Y.E.1, Nifantiev N.E.1
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隶属关系:
- Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
- XEMA Company Limited
- Kazan Scientific Research Institute of Epidemiology and Microbiology
- 期: 卷 44, 编号 1 (2018)
- 页面: 80-89
- 栏目: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228804
- DOI: https://doi.org/10.1134/S1068162017060073
- ID: 228804
如何引用文章
详细
The carbohydrate specificity of antibodies obtained by immunizing laboratory animals with immunogens prepared from the Aspergillus fumigatus cell wall was analyzed using the library of biotinylated synthetic oligosaccharides. It has been shown that the main part of antipolysaccharide antibodies recognizes galactomannan in the studied immunogens with preference to its fragments containing more than two β-(1→5)-linked galactofuranosyl units. The data obtained can form the basis for the development of enzyme immunoassay for the detection of this dangerous fungal pathogen.
作者简介
V. Krylov
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991
M. Petruk
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991
I. Grigoryev
XEMA Company Limited
Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 105264
Y. Lebedin
XEMA Company Limited
Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 105264
N. Glushko
Kazan Scientific Research Institute of Epidemiology and Microbiology
Email: nen@ioc.ac.ru
俄罗斯联邦, Kazan, 420015
E. Khaldeeva
Kazan Scientific Research Institute of Epidemiology and Microbiology
Email: nen@ioc.ac.ru
俄罗斯联邦, Kazan, 420015
D. Argunov
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991
E. Khatuntseva
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991
M. Toplishek
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991
B. Komarova
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991
A. Karelin
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991
O. Yudina
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991
V. Menshov
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991
D. Yashunskii
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991
Y. Tsvetkov
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991
N. Nifantiev
Laboratory of Glycoconjugate Chemistry, Zelinsky Institute of Organic Chemistry
编辑信件的主要联系方式.
Email: nen@ioc.ac.ru
俄罗斯联邦, Moscow, 119991
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