Polycationic amphiphiles based on triethylenetetramine and their transfection efficacy
- Authors: Puchkov P.A.1, Perevoshchikova K.A.1, Kartashova I.A.1, Luneva A.S.1, Kabilova T.O.2, Morozova N.G.1, Zenkova M.A.2, Maslov M.A.1
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Affiliations:
- Institute of Fine Chemical Technologies
- Institute of Chemical Biology and Fundamental Medicine
- Issue: Vol 43, No 5 (2017)
- Pages: 561-569
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228669
- DOI: https://doi.org/10.1134/S1068162017050107
- ID: 228669
Cite item
Abstract
Novel polycationic amphiphiles derived from triethylenetetramine, a spermine analogue, containing cholesterol or dialkylglycerol residues as hydrophilic domains were synthesized. The amphiphiles and a helper lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) served for the preparation of cationic liposomes, physicochemical properties of which were evaluated. A comparative study of cytotoxicity and transfection efficiency demonstrated that the replacement of spermine by triethylenetetramine decreased transfection activity of cationic liposomes.
About the authors
P. A. Puchkov
Institute of Fine Chemical Technologies
Email: mamaslov@mail.ru
Russian Federation, Moscow, 119571
K. A. Perevoshchikova
Institute of Fine Chemical Technologies
Email: mamaslov@mail.ru
Russian Federation, Moscow, 119571
I. A. Kartashova
Institute of Fine Chemical Technologies
Email: mamaslov@mail.ru
Russian Federation, Moscow, 119571
A. S. Luneva
Institute of Fine Chemical Technologies
Email: mamaslov@mail.ru
Russian Federation, Moscow, 119571
T. O. Kabilova
Institute of Chemical Biology and Fundamental Medicine
Email: mamaslov@mail.ru
Russian Federation, Novosibirsk, 630090
N. G. Morozova
Institute of Fine Chemical Technologies
Email: mamaslov@mail.ru
Russian Federation, Moscow, 119571
M. A. Zenkova
Institute of Chemical Biology and Fundamental Medicine
Email: mamaslov@mail.ru
Russian Federation, Novosibirsk, 630090
M. A. Maslov
Institute of Fine Chemical Technologies
Author for correspondence.
Email: mamaslov@mail.ru
Russian Federation, Moscow, 119571