Polycationic amphiphiles based on triethylenetetramine and their transfection efficacy
- Авторлар: Puchkov P.1, Perevoshchikova K.1, Kartashova I.1, Luneva A.1, Kabilova T.2, Morozova N.1, Zenkova M.2, Maslov M.1
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Мекемелер:
- Institute of Fine Chemical Technologies
- Institute of Chemical Biology and Fundamental Medicine
- Шығарылым: Том 43, № 5 (2017)
- Беттер: 561-569
- Бөлім: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228669
- DOI: https://doi.org/10.1134/S1068162017050107
- ID: 228669
Дәйексөз келтіру
Аннотация
Novel polycationic amphiphiles derived from triethylenetetramine, a spermine analogue, containing cholesterol or dialkylglycerol residues as hydrophilic domains were synthesized. The amphiphiles and a helper lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) served for the preparation of cationic liposomes, physicochemical properties of which were evaluated. A comparative study of cytotoxicity and transfection efficiency demonstrated that the replacement of spermine by triethylenetetramine decreased transfection activity of cationic liposomes.
Авторлар туралы
P. Puchkov
Institute of Fine Chemical Technologies
Email: mamaslov@mail.ru
Ресей, Moscow, 119571
K. Perevoshchikova
Institute of Fine Chemical Technologies
Email: mamaslov@mail.ru
Ресей, Moscow, 119571
I. Kartashova
Institute of Fine Chemical Technologies
Email: mamaslov@mail.ru
Ресей, Moscow, 119571
A. Luneva
Institute of Fine Chemical Technologies
Email: mamaslov@mail.ru
Ресей, Moscow, 119571
T. Kabilova
Institute of Chemical Biology and Fundamental Medicine
Email: mamaslov@mail.ru
Ресей, Novosibirsk, 630090
N. Morozova
Institute of Fine Chemical Technologies
Email: mamaslov@mail.ru
Ресей, Moscow, 119571
M. Zenkova
Institute of Chemical Biology and Fundamental Medicine
Email: mamaslov@mail.ru
Ресей, Novosibirsk, 630090
M. Maslov
Institute of Fine Chemical Technologies
Хат алмасуға жауапты Автор.
Email: mamaslov@mail.ru
Ресей, Moscow, 119571