Polycationic amphiphiles based on triethylenetetramine and their transfection efficacy
- Авторы: Puchkov P.1, Perevoshchikova K.1, Kartashova I.1, Luneva A.1, Kabilova T.2, Morozova N.1, Zenkova M.2, Maslov M.1
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Учреждения:
- Institute of Fine Chemical Technologies
- Institute of Chemical Biology and Fundamental Medicine
- Выпуск: Том 43, № 5 (2017)
- Страницы: 561-569
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228669
- DOI: https://doi.org/10.1134/S1068162017050107
- ID: 228669
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Аннотация
Novel polycationic amphiphiles derived from triethylenetetramine, a spermine analogue, containing cholesterol or dialkylglycerol residues as hydrophilic domains were synthesized. The amphiphiles and a helper lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) served for the preparation of cationic liposomes, physicochemical properties of which were evaluated. A comparative study of cytotoxicity and transfection efficiency demonstrated that the replacement of spermine by triethylenetetramine decreased transfection activity of cationic liposomes.
Об авторах
P. Puchkov
Institute of Fine Chemical Technologies
Email: mamaslov@mail.ru
Россия, Moscow, 119571
K. Perevoshchikova
Institute of Fine Chemical Technologies
Email: mamaslov@mail.ru
Россия, Moscow, 119571
I. Kartashova
Institute of Fine Chemical Technologies
Email: mamaslov@mail.ru
Россия, Moscow, 119571
A. Luneva
Institute of Fine Chemical Technologies
Email: mamaslov@mail.ru
Россия, Moscow, 119571
T. Kabilova
Institute of Chemical Biology and Fundamental Medicine
Email: mamaslov@mail.ru
Россия, Novosibirsk, 630090
N. Morozova
Institute of Fine Chemical Technologies
Email: mamaslov@mail.ru
Россия, Moscow, 119571
M. Zenkova
Institute of Chemical Biology and Fundamental Medicine
Email: mamaslov@mail.ru
Россия, Novosibirsk, 630090
M. Maslov
Institute of Fine Chemical Technologies
Автор, ответственный за переписку.
Email: mamaslov@mail.ru
Россия, Moscow, 119571