Synthesis of paricalcitol: A novel strategy combining chemical and microbial transformations


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Abstract

A novel strategy was developed for the preparation of paricalcitol (1α,25-dihydroxy-19-norvitamin D2) via seven-step chemical transformation and one-step microbial transformation. Using vitamin D2 as a starting material, 1α- and 25-hydroxyl groups of paricalcitol were introduced by Pseudonocardia autotrophica CGMCC5098 at the late stage of the synthesis, allowing us to avoid harsh reaction conditions and tedious steps. The overall yield of paricalcitol was 0.75%.

About the authors

J. Q. Luo

Department of Сhemistry, School of Life Science and Engineering

Email: luqun1125@home.swjtu.edu.cn
China, Chengdu, 610031

F. Jiang

Department of Сhemistry, School of Life Science and Engineering

Email: luqun1125@home.swjtu.edu.cn
China, Chengdu, 610031

W. Q. Song

Department of Сhemistry, School of Life Science and Engineering

Email: luqun1125@home.swjtu.edu.cn
China, Chengdu, 610031

W. Z. Fang

Department of Сhemistry, School of Life Science and Engineering

Author for correspondence.
Email: fangweizhen@home.swjtu.edu.cn
China, Chengdu, 610031

Q. Lu

Department of Сhemistry, School of Life Science and Engineering

Author for correspondence.
Email: luqun1125@home.swjtu.edu.cn
China, Chengdu, 610031

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