Email this article Synthesis of paricalcitol: A novel strategy combining chemical and microbial transformations
- Authors: Luo J.Q.1, Jiang F.1, Song W.Q.1, Fang W.Z.1, Lu Q.1
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Affiliations:
- Department of Сhemistry, School of Life Science and Engineering
- Issue: Vol 43, No 3 (2017)
- Pages: 323-327
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228543
- DOI: https://doi.org/10.1134/S1068162017030104
- ID: 228543
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Abstract
A novel strategy was developed for the preparation of paricalcitol (1α,25-dihydroxy-19-norvitamin D2) via seven-step chemical transformation and one-step microbial transformation. Using vitamin D2 as a starting material, 1α- and 25-hydroxyl groups of paricalcitol were introduced by Pseudonocardia autotrophica CGMCC5098 at the late stage of the synthesis, allowing us to avoid harsh reaction conditions and tedious steps. The overall yield of paricalcitol was 0.75%.
About the authors
J. Q. Luo
Department of Сhemistry, School of Life Science and Engineering
Email: luqun1125@home.swjtu.edu.cn
China, Chengdu, 610031
F. Jiang
Department of Сhemistry, School of Life Science and Engineering
Email: luqun1125@home.swjtu.edu.cn
China, Chengdu, 610031
W. Q. Song
Department of Сhemistry, School of Life Science and Engineering
Email: luqun1125@home.swjtu.edu.cn
China, Chengdu, 610031
W. Z. Fang
Department of Сhemistry, School of Life Science and Engineering
Author for correspondence.
Email: fangweizhen@home.swjtu.edu.cn
China, Chengdu, 610031
Q. Lu
Department of Сhemistry, School of Life Science and Engineering
Author for correspondence.
Email: luqun1125@home.swjtu.edu.cn
China, Chengdu, 610031
