Мақаланы E-mail арқылы жіберу Synthesis of paricalcitol: A novel strategy combining chemical and microbial transformations
- Авторлар: Luo J.Q.1, Jiang F.1, Song W.Q.1, Fang W.Z.1, Lu Q.1
-
Мекемелер:
- Department of Сhemistry, School of Life Science and Engineering
- Шығарылым: Том 43, № 3 (2017)
- Беттер: 323-327
- Бөлім: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228543
- DOI: https://doi.org/10.1134/S1068162017030104
- ID: 228543
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
A novel strategy was developed for the preparation of paricalcitol (1α,25-dihydroxy-19-norvitamin D2) via seven-step chemical transformation and one-step microbial transformation. Using vitamin D2 as a starting material, 1α- and 25-hydroxyl groups of paricalcitol were introduced by Pseudonocardia autotrophica CGMCC5098 at the late stage of the synthesis, allowing us to avoid harsh reaction conditions and tedious steps. The overall yield of paricalcitol was 0.75%.
Негізгі сөздер
Авторлар туралы
J. Luo
Department of Сhemistry, School of Life Science and Engineering
Email: luqun1125@home.swjtu.edu.cn
ҚХР, Chengdu, 610031
F. Jiang
Department of Сhemistry, School of Life Science and Engineering
Email: luqun1125@home.swjtu.edu.cn
ҚХР, Chengdu, 610031
W. Song
Department of Сhemistry, School of Life Science and Engineering
Email: luqun1125@home.swjtu.edu.cn
ҚХР, Chengdu, 610031
W. Fang
Department of Сhemistry, School of Life Science and Engineering
Хат алмасуға жауапты Автор.
Email: fangweizhen@home.swjtu.edu.cn
ҚХР, Chengdu, 610031
Q. Lu
Department of Сhemistry, School of Life Science and Engineering
Хат алмасуға жауапты Автор.
Email: luqun1125@home.swjtu.edu.cn
ҚХР, Chengdu, 610031
Қосымша файлдар
