Synthesis of paricalcitol: A novel strategy combining chemical and microbial transformations
- Авторы: Luo J.1, Jiang F.1, Song W.1, Fang W.1, Lu Q.1
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Учреждения:
- Department of Сhemistry, School of Life Science and Engineering
- Выпуск: Том 43, № 3 (2017)
- Страницы: 323-327
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228543
- DOI: https://doi.org/10.1134/S1068162017030104
- ID: 228543
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Аннотация
A novel strategy was developed for the preparation of paricalcitol (1α,25-dihydroxy-19-norvitamin D2) via seven-step chemical transformation and one-step microbial transformation. Using vitamin D2 as a starting material, 1α- and 25-hydroxyl groups of paricalcitol were introduced by Pseudonocardia autotrophica CGMCC5098 at the late stage of the synthesis, allowing us to avoid harsh reaction conditions and tedious steps. The overall yield of paricalcitol was 0.75%.
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Об авторах
J. Luo
Department of Сhemistry, School of Life Science and Engineering
Email: luqun1125@home.swjtu.edu.cn
Китай, Chengdu, 610031
F. Jiang
Department of Сhemistry, School of Life Science and Engineering
Email: luqun1125@home.swjtu.edu.cn
Китай, Chengdu, 610031
W. Song
Department of Сhemistry, School of Life Science and Engineering
Email: luqun1125@home.swjtu.edu.cn
Китай, Chengdu, 610031
W. Fang
Department of Сhemistry, School of Life Science and Engineering
Автор, ответственный за переписку.
Email: fangweizhen@home.swjtu.edu.cn
Китай, Chengdu, 610031
Q. Lu
Department of Сhemistry, School of Life Science and Engineering
Автор, ответственный за переписку.
Email: luqun1125@home.swjtu.edu.cn
Китай, Chengdu, 610031