Conformationally locked GFP chromophore derivatives as potential fluorescent sensors
- Authors: Baleeva N.S.1, Yampolsky I.V.1,2, Baranov M.S.1,2
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Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Pirogov Russian National Research Medical University
- Issue: Vol 42, No 4 (2016)
- Pages: 453-456
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228078
- DOI: https://doi.org/10.1134/S1068162016040051
- ID: 228078
Cite item
Abstract
We propose to use the conformationally locked GFP chromophore derivatives (4-(2(difluoroboryl)benzylidene)-1H-imidazol-5(4H)-ones) as potential fluorescent sensors. The model carbamate derivatives were synthesized and their fluorescent properties were studied. It was shown that the introduction/cleavage of the carbamate groups at the nitrogen atom led to the noticeable shifts in the absorption and emission maxima of the resultant derivatives, which makes them promising candidates for new fluorescent sensors.
Keywords
About the authors
N. S. Baleeva
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: baranovmikes@gmail.com
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997
I. V. Yampolsky
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Pirogov Russian National Research Medical University
Email: baranovmikes@gmail.com
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997; Ostrovityanova 1, Moscow, 117997
M. S. Baranov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Pirogov Russian National Research Medical University
Author for correspondence.
Email: baranovmikes@gmail.com
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997; Ostrovityanova 1, Moscow, 117997