Email this article The derivatives of imidazo[1,2-a]benzimidazole as 5-HT2A receptor antagonists
- Authors: Spasov A.A.1,2, Yakovlev D.S.1,2, Maltsev D.V.1,2, Zhukovskaya O.N.3, Anisimova V.A.3, Kovalev G.I.4, Zimin I.A.4, Morkovina Y.V.1,3
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Affiliations:
- Volgograd Medical Research Center
- Volgograd State Medical University
- Research Institute of Physical and Organic Chemistry at Southern Federal University
- Zakusov Institute of Pharmacology
- Issue: Vol 42, No 4 (2016)
- Pages: 397-403
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228014
- DOI: https://doi.org/10.1134/S1068162016040178
- ID: 228014
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Abstract
We studied in vitro the 5-HT2A antagonistic activity of 16 imidazo[1,2-a]benzimidazole derivatives. Using the radioligand method we showed the binding of 9-(2-diethylaminoethyl)-2-(4-methoxyphenyl)imidazo[1,2-a]benzimidazol dinitrate to the 2A subtype serotonin receptor.
About the authors
A. A. Spasov
Volgograd Medical Research Center; Volgograd State Medical University
Email: dypharm@list.ru
Russian Federation, pl. Pavshikh Bortsov 1, Volgograd, 400131; pl. Pavshikh Bortsov 1, Volgograd, 400131
D. S. Yakovlev
Volgograd Medical Research Center; Volgograd State Medical University
Author for correspondence.
Email: dypharm@list.ru
Russian Federation, pl. Pavshikh Bortsov 1, Volgograd, 400131; pl. Pavshikh Bortsov 1, Volgograd, 400131
D. V. Maltsev
Volgograd Medical Research Center; Volgograd State Medical University
Email: dypharm@list.ru
Russian Federation, pl. Pavshikh Bortsov 1, Volgograd, 400131; pl. Pavshikh Bortsov 1, Volgograd, 400131
O. N. Zhukovskaya
Research Institute of Physical and Organic Chemistry at Southern Federal University
Email: dypharm@list.ru
Russian Federation, pr. Stachky 194/2, Rostov-on-Don, 344090
V. A. Anisimova
Research Institute of Physical and Organic Chemistry at Southern Federal University
Email: dypharm@list.ru
Russian Federation, pr. Stachky 194/2, Rostov-on-Don, 344090
G. I. Kovalev
Zakusov Institute of Pharmacology
Email: dypharm@list.ru
Russian Federation, ul. Baltiyskaya 8, Moscow, 125315
I. A. Zimin
Zakusov Institute of Pharmacology
Email: dypharm@list.ru
Russian Federation, ul. Baltiyskaya 8, Moscow, 125315
Y. V. Morkovina
Volgograd Medical Research Center; Research Institute of Physical and Organic Chemistry at Southern Federal University
Email: dypharm@list.ru
Russian Federation, pl. Pavshikh Bortsov 1, Volgograd, 400131; pr. Stachky 194/2, Rostov-on-Don, 344090
