The derivatives of imidazo[1,2-a]benzimidazole as 5-HT2A receptor antagonists


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We studied in vitro the 5-HT2A antagonistic activity of 16 imidazo[1,2-a]benzimidazole derivatives. Using the radioligand method we showed the binding of 9-(2-diethylaminoethyl)-2-(4-methoxyphenyl)imidazo[1,2-a]benzimidazol dinitrate to the 2A subtype serotonin receptor.

作者简介

A. Spasov

Volgograd Medical Research Center; Volgograd State Medical University

Email: dypharm@list.ru
俄罗斯联邦, pl. Pavshikh Bortsov 1, Volgograd, 400131; pl. Pavshikh Bortsov 1, Volgograd, 400131

D. Yakovlev

Volgograd Medical Research Center; Volgograd State Medical University

编辑信件的主要联系方式.
Email: dypharm@list.ru
俄罗斯联邦, pl. Pavshikh Bortsov 1, Volgograd, 400131; pl. Pavshikh Bortsov 1, Volgograd, 400131

D. Maltsev

Volgograd Medical Research Center; Volgograd State Medical University

Email: dypharm@list.ru
俄罗斯联邦, pl. Pavshikh Bortsov 1, Volgograd, 400131; pl. Pavshikh Bortsov 1, Volgograd, 400131

O. Zhukovskaya

Research Institute of Physical and Organic Chemistry at Southern Federal University

Email: dypharm@list.ru
俄罗斯联邦, pr. Stachky 194/2, Rostov-on-Don, 344090

V. Anisimova

Research Institute of Physical and Organic Chemistry at Southern Federal University

Email: dypharm@list.ru
俄罗斯联邦, pr. Stachky 194/2, Rostov-on-Don, 344090

G. Kovalev

Zakusov Institute of Pharmacology

Email: dypharm@list.ru
俄罗斯联邦, ul. Baltiyskaya 8, Moscow, 125315

I. Zimin

Zakusov Institute of Pharmacology

Email: dypharm@list.ru
俄罗斯联邦, ul. Baltiyskaya 8, Moscow, 125315

Y. Morkovina

Volgograd Medical Research Center; Research Institute of Physical and Organic Chemistry at Southern Federal University

Email: dypharm@list.ru
俄罗斯联邦, pl. Pavshikh Bortsov 1, Volgograd, 400131; pr. Stachky 194/2, Rostov-on-Don, 344090

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