Enviar artigo por via de e-mail The derivatives of imidazo[1,2-a]benzimidazole as 5-HT2A receptor antagonists
- Autores: Spasov A.1,2, Yakovlev D.1,2, Maltsev D.1,2, Zhukovskaya O.3, Anisimova V.3, Kovalev G.4, Zimin I.4, Morkovina Y.1,3
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Afiliações:
- Volgograd Medical Research Center
- Volgograd State Medical University
- Research Institute of Physical and Organic Chemistry at Southern Federal University
- Zakusov Institute of Pharmacology
- Edição: Volume 42, Nº 4 (2016)
- Páginas: 397-403
- Seção: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228014
- DOI: https://doi.org/10.1134/S1068162016040178
- ID: 228014
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Resumo
We studied in vitro the 5-HT2A antagonistic activity of 16 imidazo[1,2-a]benzimidazole derivatives. Using the radioligand method we showed the binding of 9-(2-diethylaminoethyl)-2-(4-methoxyphenyl)imidazo[1,2-a]benzimidazol dinitrate to the 2A subtype serotonin receptor.
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Sobre autores
A. Spasov
Volgograd Medical Research Center; Volgograd State Medical University
Email: dypharm@list.ru
Rússia, pl. Pavshikh Bortsov 1, Volgograd, 400131; pl. Pavshikh Bortsov 1, Volgograd, 400131
D. Yakovlev
Volgograd Medical Research Center; Volgograd State Medical University
Autor responsável pela correspondência
Email: dypharm@list.ru
Rússia, pl. Pavshikh Bortsov 1, Volgograd, 400131; pl. Pavshikh Bortsov 1, Volgograd, 400131
D. Maltsev
Volgograd Medical Research Center; Volgograd State Medical University
Email: dypharm@list.ru
Rússia, pl. Pavshikh Bortsov 1, Volgograd, 400131; pl. Pavshikh Bortsov 1, Volgograd, 400131
O. Zhukovskaya
Research Institute of Physical and Organic Chemistry at Southern Federal University
Email: dypharm@list.ru
Rússia, pr. Stachky 194/2, Rostov-on-Don, 344090
V. Anisimova
Research Institute of Physical and Organic Chemistry at Southern Federal University
Email: dypharm@list.ru
Rússia, pr. Stachky 194/2, Rostov-on-Don, 344090
G. Kovalev
Zakusov Institute of Pharmacology
Email: dypharm@list.ru
Rússia, ul. Baltiyskaya 8, Moscow, 125315
I. Zimin
Zakusov Institute of Pharmacology
Email: dypharm@list.ru
Rússia, ul. Baltiyskaya 8, Moscow, 125315
Y. Morkovina
Volgograd Medical Research Center; Research Institute of Physical and Organic Chemistry at Southern Federal University
Email: dypharm@list.ru
Rússia, pl. Pavshikh Bortsov 1, Volgograd, 400131; pr. Stachky 194/2, Rostov-on-Don, 344090
