Synthesis of 14ß-cyanomethyl derivatives of estradiol and the estimation of their antineoplastic activity in vitro

A. V. Baranovsky; V. N. Bil’dyukevich; M. B. Golubeva; B. B. Kuzmitsky; Yu. Yu. Mamchits

doi:10.1134/S1068162015060023

Synthesis of 14ß-cyanomethyl derivatives of estradiol and the estimation of their antineoplastic activity in vitro

Authors: Baranovsky A.V.¹, Bil’dyukevich V.N.¹, Golubeva M.B.¹, Kuzmitsky B.B.¹, Mamchits Y.Y.¹
Affiliations:
1. Institute of Bioorganic Chemistry
Issue: Vol 42, No 1 (2016)
Pages: 83-92
Section: Article
URL: https://journals.rcsi.science/1068-1620/article/view/227817
DOI: https://doi.org/10.1134/S1068162015060023
ID: 227817

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Abstract

14ß-Cyanomethyl derivatives of estrone and estradiol have been synthesized starting from 3-benzoyloxyestra-1,3,5(10),14,16-pentaen-17-yl acetate. A comparative study of their cytotoxicity in breast carcinoma ZR-75-1, cervix uteri carcinoma M-HeLa, uterus leiomyosarcoma SK-UT-1B, breast adenocarcinoma MCF-7, ovary teratocarcinoma PA-1, acute myelogenous leukemia KG-1, and Burkitt’s lymphoma Raji cells has been performed.