Enviar artigo por via de e-mail Synthesis of 14ß-cyanomethyl derivatives of estradiol and the estimation of their antineoplastic activity in vitro
- Autores: Baranovsky A.1, Bil’dyukevich V.1, Golubeva M.1, Kuzmitsky B.1, Mamchits Y.1
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Afiliações:
- Institute of Bioorganic Chemistry
- Edição: Volume 42, Nº 1 (2016)
- Páginas: 83-92
- Seção: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/227817
- DOI: https://doi.org/10.1134/S1068162015060023
- ID: 227817
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Resumo
14ß-Cyanomethyl derivatives of estrone and estradiol have been synthesized starting from 3-benzoyloxyestra-1,3,5(10),14,16-pentaen-17-yl acetate. A comparative study of their cytotoxicity in breast carcinoma ZR-75-1, cervix uteri carcinoma M-HeLa, uterus leiomyosarcoma SK-UT-1B, breast adenocarcinoma MCF-7, ovary teratocarcinoma PA-1, acute myelogenous leukemia KG-1, and Burkitt’s lymphoma Raji cells has been performed.
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Sobre autores
A. Baranovsky
Institute of Bioorganic Chemistry
Autor responsável pela correspondência
Email: baranovsky@iboch.bas-net.by
Belarus, ul. Kuprevicha 5/2, Minsk, 220141
V. Bil’dyukevich
Institute of Bioorganic Chemistry
Email: baranovsky@iboch.bas-net.by
Belarus, ul. Kuprevicha 5/2, Minsk, 220141
M. Golubeva
Institute of Bioorganic Chemistry
Email: baranovsky@iboch.bas-net.by
Belarus, ul. Kuprevicha 5/2, Minsk, 220141
B. Kuzmitsky
Institute of Bioorganic Chemistry
Email: baranovsky@iboch.bas-net.by
Belarus, ul. Kuprevicha 5/2, Minsk, 220141
Yu. Mamchits
Institute of Bioorganic Chemistry
Email: baranovsky@iboch.bas-net.by
Belarus, ul. Kuprevicha 5/2, Minsk, 220141
