Synthesis and properties of 1,2-dihydro-4(3H)-quinazolinones
- 作者: Khachatryan D.1, Belus S.1, Misyurin V.2, Baryshnikova M.2, Kolotaev A.1, Matevosyan K.3
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隶属关系:
- Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
- N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
- D. Mendeleev University of Chemical Technology of Russia
- 期: 卷 66, 编号 6 (2017)
- 页面: 1044-1058
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/240747
- DOI: https://doi.org/10.1007/s11172-017-1852-2
- ID: 240747
如何引用文章
详细
We modified the preparative-scale method for the synthesis of 2-aryl 1,2-dihydro-4(3H)-quinazolinone derivatives obtained in high yields by the reaction of new and commercially available aromatic aldehydes with anthranilic acid amides. A series of quinazolinone derivatives possessing anticancer and antiparasitic activities, as well as capable of preventing the progress of neurodegenerative diseases were characterized. There are grounds for clinical trials of these substances in order to select compounds being promising for clinical application.
作者简介
D. Khachatryan
Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
编辑信件的主要联系方式.
Email: derenik-s@yandex.ru
俄罗斯联邦, 3 Bogorodskii val, Moscow, 107076
S. Belus
Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Email: derenik-s@yandex.ru
俄罗斯联邦, 3 Bogorodskii val, Moscow, 107076
V. Misyurin
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: derenik-s@yandex.ru
俄罗斯联邦, 24 Kashirskoe sh., Moscow, 115478
M. Baryshnikova
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: derenik-s@yandex.ru
俄罗斯联邦, 24 Kashirskoe sh., Moscow, 115478
A. Kolotaev
Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Email: derenik-s@yandex.ru
俄罗斯联邦, 3 Bogorodskii val, Moscow, 107076
K. Matevosyan
D. Mendeleev University of Chemical Technology of Russia
Email: derenik-s@yandex.ru
俄罗斯联邦, 9 Miusskaya pl., Moscow, 125047