Synthesis and properties of 1,2-dihydro-4(3H)-quinazolinones
- Авторы: Khachatryan D.1, Belus S.1, Misyurin V.2, Baryshnikova M.2, Kolotaev A.1, Matevosyan K.3
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Учреждения:
- Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
- N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
- D. Mendeleev University of Chemical Technology of Russia
- Выпуск: Том 66, № 6 (2017)
- Страницы: 1044-1058
- Раздел: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/240747
- DOI: https://doi.org/10.1007/s11172-017-1852-2
- ID: 240747
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Аннотация
We modified the preparative-scale method for the synthesis of 2-aryl 1,2-dihydro-4(3H)-quinazolinone derivatives obtained in high yields by the reaction of new and commercially available aromatic aldehydes with anthranilic acid amides. A series of quinazolinone derivatives possessing anticancer and antiparasitic activities, as well as capable of preventing the progress of neurodegenerative diseases were characterized. There are grounds for clinical trials of these substances in order to select compounds being promising for clinical application.
Об авторах
D. Khachatryan
Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Автор, ответственный за переписку.
Email: derenik-s@yandex.ru
Россия, 3 Bogorodskii val, Moscow, 107076
S. Belus
Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Email: derenik-s@yandex.ru
Россия, 3 Bogorodskii val, Moscow, 107076
V. Misyurin
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: derenik-s@yandex.ru
Россия, 24 Kashirskoe sh., Moscow, 115478
M. Baryshnikova
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: derenik-s@yandex.ru
Россия, 24 Kashirskoe sh., Moscow, 115478
A. Kolotaev
Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Email: derenik-s@yandex.ru
Россия, 3 Bogorodskii val, Moscow, 107076
K. Matevosyan
D. Mendeleev University of Chemical Technology of Russia
Email: derenik-s@yandex.ru
Россия, 9 Miusskaya pl., Moscow, 125047