Synthesis and properties of 1,2-dihydro-4(3H)-quinazolinones
- Autores: Khachatryan D.1, Belus S.1, Misyurin V.2, Baryshnikova M.2, Kolotaev A.1, Matevosyan K.3
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Afiliações:
- Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
- N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
- D. Mendeleev University of Chemical Technology of Russia
- Edição: Volume 66, Nº 6 (2017)
- Páginas: 1044-1058
- Seção: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/240747
- DOI: https://doi.org/10.1007/s11172-017-1852-2
- ID: 240747
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Resumo
We modified the preparative-scale method for the synthesis of 2-aryl 1,2-dihydro-4(3H)-quinazolinone derivatives obtained in high yields by the reaction of new and commercially available aromatic aldehydes with anthranilic acid amides. A series of quinazolinone derivatives possessing anticancer and antiparasitic activities, as well as capable of preventing the progress of neurodegenerative diseases were characterized. There are grounds for clinical trials of these substances in order to select compounds being promising for clinical application.
Sobre autores
D. Khachatryan
Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Autor responsável pela correspondência
Email: derenik-s@yandex.ru
Rússia, 3 Bogorodskii val, Moscow, 107076
S. Belus
Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Email: derenik-s@yandex.ru
Rússia, 3 Bogorodskii val, Moscow, 107076
V. Misyurin
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: derenik-s@yandex.ru
Rússia, 24 Kashirskoe sh., Moscow, 115478
M. Baryshnikova
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: derenik-s@yandex.ru
Rússia, 24 Kashirskoe sh., Moscow, 115478
A. Kolotaev
Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Email: derenik-s@yandex.ru
Rússia, 3 Bogorodskii val, Moscow, 107076
K. Matevosyan
D. Mendeleev University of Chemical Technology of Russia
Email: derenik-s@yandex.ru
Rússia, 9 Miusskaya pl., Moscow, 125047