Synthesis and properties of 1,2-dihydro-4(3H)-quinazolinones
- Авторлар: Khachatryan D.1, Belus S.1, Misyurin V.2, Baryshnikova M.2, Kolotaev A.1, Matevosyan K.3
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Мекемелер:
- Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
- N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
- D. Mendeleev University of Chemical Technology of Russia
- Шығарылым: Том 66, № 6 (2017)
- Беттер: 1044-1058
- Бөлім: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/240747
- DOI: https://doi.org/10.1007/s11172-017-1852-2
- ID: 240747
Дәйексөз келтіру
Аннотация
We modified the preparative-scale method for the synthesis of 2-aryl 1,2-dihydro-4(3H)-quinazolinone derivatives obtained in high yields by the reaction of new and commercially available aromatic aldehydes with anthranilic acid amides. A series of quinazolinone derivatives possessing anticancer and antiparasitic activities, as well as capable of preventing the progress of neurodegenerative diseases were characterized. There are grounds for clinical trials of these substances in order to select compounds being promising for clinical application.
Авторлар туралы
D. Khachatryan
Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Хат алмасуға жауапты Автор.
Email: derenik-s@yandex.ru
Ресей, 3 Bogorodskii val, Moscow, 107076
S. Belus
Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Email: derenik-s@yandex.ru
Ресей, 3 Bogorodskii val, Moscow, 107076
V. Misyurin
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: derenik-s@yandex.ru
Ресей, 24 Kashirskoe sh., Moscow, 115478
M. Baryshnikova
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: derenik-s@yandex.ru
Ресей, 24 Kashirskoe sh., Moscow, 115478
A. Kolotaev
Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Email: derenik-s@yandex.ru
Ресей, 3 Bogorodskii val, Moscow, 107076
K. Matevosyan
D. Mendeleev University of Chemical Technology of Russia
Email: derenik-s@yandex.ru
Ресей, 9 Miusskaya pl., Moscow, 125047