Отправить статью по E-mail Composition and properties of the reaction products of p-cresol with camphene
- Авторы: Chukicheva I.Y.1, Buravlev E.V.1, Dvornikova I.A.1, Fedorova I.V.1, Chernysheva G.A.2, Aliev O.I.2, Smol’yakova V.I.2, Anishchenko A.M.2, Sidekhmenova A.V.2, Plotnikov M.B.2, Kutchin A.V.1
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Учреждения:
- Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
- Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
- Выпуск: Том 68, № 5 (2019)
- Страницы: 993-999
- Раздел: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243370
- DOI: https://doi.org/10.1007/s11172-019-2509-0
- ID: 243370
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Аннотация
The products of the reaction between p-cresol and camphene were isolated and characterized. Their antiradical activity and toxicity were studied. The pharmacological activity of the most active stereoisomer of 2,6-diisobornyl-4-methyl phenol in rats with a model of streptozotocin diabetes was studied. Under these conditions, the investigated compound during course administration improves micro- and macrorheological parameters of blood, exhibits a membranestabilizing eff ect on erythrocytes, restricts platelet aggregation, and favors the preservation of the vasodilator function of endothelium.
Об авторах
I. Chukicheva
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Автор, ответственный за переписку.
Email: chukichevaiy@mail.ru
Россия, 48 ul. Pervomayskaya, Syktyvkar, 167000
E. Buravlev
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Россия, 48 ul. Pervomayskaya, Syktyvkar, 167000
I. Dvornikova
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Россия, 48 ul. Pervomayskaya, Syktyvkar, 167000
I. Fedorova
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Россия, 48 ul. Pervomayskaya, Syktyvkar, 167000
G. Chernysheva
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Россия, 3 pr. Lenina, Tomsk, 634050
O. Aliev
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Россия, 3 pr. Lenina, Tomsk, 634050
V. Smol’yakova
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Россия, 3 pr. Lenina, Tomsk, 634050
A. Anishchenko
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Россия, 3 pr. Lenina, Tomsk, 634050
A. Sidekhmenova
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Россия, 3 pr. Lenina, Tomsk, 634050
M. Plotnikov
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Россия, 3 pr. Lenina, Tomsk, 634050
A. Kutchin
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Россия, 48 ul. Pervomayskaya, Syktyvkar, 167000
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