Мақаланы E-mail арқылы жіберу Composition and properties of the reaction products of p-cresol with camphene
- Авторлар: Chukicheva I.Y.1, Buravlev E.V.1, Dvornikova I.A.1, Fedorova I.V.1, Chernysheva G.A.2, Aliev O.I.2, Smol’yakova V.I.2, Anishchenko A.M.2, Sidekhmenova A.V.2, Plotnikov M.B.2, Kutchin A.V.1
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Мекемелер:
- Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
- Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
- Шығарылым: Том 68, № 5 (2019)
- Беттер: 993-999
- Бөлім: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243370
- DOI: https://doi.org/10.1007/s11172-019-2509-0
- ID: 243370
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Аннотация
The products of the reaction between p-cresol and camphene were isolated and characterized. Their antiradical activity and toxicity were studied. The pharmacological activity of the most active stereoisomer of 2,6-diisobornyl-4-methyl phenol in rats with a model of streptozotocin diabetes was studied. Under these conditions, the investigated compound during course administration improves micro- and macrorheological parameters of blood, exhibits a membranestabilizing eff ect on erythrocytes, restricts platelet aggregation, and favors the preservation of the vasodilator function of endothelium.
Авторлар туралы
I. Chukicheva
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: chukichevaiy@mail.ru
Ресей, 48 ul. Pervomayskaya, Syktyvkar, 167000
E. Buravlev
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Ресей, 48 ul. Pervomayskaya, Syktyvkar, 167000
I. Dvornikova
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Ресей, 48 ul. Pervomayskaya, Syktyvkar, 167000
I. Fedorova
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Ресей, 48 ul. Pervomayskaya, Syktyvkar, 167000
G. Chernysheva
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Ресей, 3 pr. Lenina, Tomsk, 634050
O. Aliev
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Ресей, 3 pr. Lenina, Tomsk, 634050
V. Smol’yakova
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Ресей, 3 pr. Lenina, Tomsk, 634050
A. Anishchenko
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Ресей, 3 pr. Lenina, Tomsk, 634050
A. Sidekhmenova
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Ресей, 3 pr. Lenina, Tomsk, 634050
M. Plotnikov
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Ресей, 3 pr. Lenina, Tomsk, 634050
A. Kutchin
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Ресей, 48 ul. Pervomayskaya, Syktyvkar, 167000
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