Enviar artigo por via de e-mail Composition and properties of the reaction products of p-cresol with camphene
- Autores: Chukicheva I.1, Buravlev E.1, Dvornikova I.1, Fedorova I.1, Chernysheva G.2, Aliev O.2, Smol’yakova V.2, Anishchenko A.2, Sidekhmenova A.2, Plotnikov M.2, Kutchin A.1
-
Afiliações:
- Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
- Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
- Edição: Volume 68, Nº 5 (2019)
- Páginas: 993-999
- Seção: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243370
- DOI: https://doi.org/10.1007/s11172-019-2509-0
- ID: 243370
Citar
Acesso aberto
Acesso está concedido
Somente assinantes
Resumo
The products of the reaction between p-cresol and camphene were isolated and characterized. Their antiradical activity and toxicity were studied. The pharmacological activity of the most active stereoisomer of 2,6-diisobornyl-4-methyl phenol in rats with a model of streptozotocin diabetes was studied. Under these conditions, the investigated compound during course administration improves micro- and macrorheological parameters of blood, exhibits a membranestabilizing eff ect on erythrocytes, restricts platelet aggregation, and favors the preservation of the vasodilator function of endothelium.
Sobre autores
I. Chukicheva
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: chukichevaiy@mail.ru
Rússia, 48 ul. Pervomayskaya, Syktyvkar, 167000
E. Buravlev
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 48 ul. Pervomayskaya, Syktyvkar, 167000
I. Dvornikova
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 48 ul. Pervomayskaya, Syktyvkar, 167000
I. Fedorova
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 48 ul. Pervomayskaya, Syktyvkar, 167000
G. Chernysheva
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 3 pr. Lenina, Tomsk, 634050
O. Aliev
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 3 pr. Lenina, Tomsk, 634050
V. Smol’yakova
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 3 pr. Lenina, Tomsk, 634050
A. Anishchenko
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 3 pr. Lenina, Tomsk, 634050
A. Sidekhmenova
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 3 pr. Lenina, Tomsk, 634050
M. Plotnikov
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 3 pr. Lenina, Tomsk, 634050
A. Kutchin
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Rússia, 48 ul. Pervomayskaya, Syktyvkar, 167000
