Email this article Composition and properties of the reaction products of p-cresol with camphene
- Authors: Chukicheva I.Y.1, Buravlev E.V.1, Dvornikova I.A.1, Fedorova I.V.1, Chernysheva G.A.2, Aliev O.I.2, Smol’yakova V.I.2, Anishchenko A.M.2, Sidekhmenova A.V.2, Plotnikov M.B.2, Kutchin A.V.1
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Affiliations:
- Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
- Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
- Issue: Vol 68, No 5 (2019)
- Pages: 993-999
- Section: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243370
- DOI: https://doi.org/10.1007/s11172-019-2509-0
- ID: 243370
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Abstract
The products of the reaction between p-cresol and camphene were isolated and characterized. Their antiradical activity and toxicity were studied. The pharmacological activity of the most active stereoisomer of 2,6-diisobornyl-4-methyl phenol in rats with a model of streptozotocin diabetes was studied. Under these conditions, the investigated compound during course administration improves micro- and macrorheological parameters of blood, exhibits a membranestabilizing eff ect on erythrocytes, restricts platelet aggregation, and favors the preservation of the vasodilator function of endothelium.
About the authors
I. Yu. Chukicheva
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Author for correspondence.
Email: chukichevaiy@mail.ru
Russian Federation, 48 ul. Pervomayskaya, Syktyvkar, 167000
E. V. Buravlev
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 48 ul. Pervomayskaya, Syktyvkar, 167000
I. A. Dvornikova
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 48 ul. Pervomayskaya, Syktyvkar, 167000
I. V. Fedorova
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 48 ul. Pervomayskaya, Syktyvkar, 167000
G. A. Chernysheva
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 3 pr. Lenina, Tomsk, 634050
O. I. Aliev
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 3 pr. Lenina, Tomsk, 634050
V. I. Smol’yakova
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 3 pr. Lenina, Tomsk, 634050
A. M. Anishchenko
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 3 pr. Lenina, Tomsk, 634050
A. V. Sidekhmenova
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 3 pr. Lenina, Tomsk, 634050
M. B. Plotnikov
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 3 pr. Lenina, Tomsk, 634050
A. V. Kutchin
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: chukichevaiy@mail.ru
Russian Federation, 48 ul. Pervomayskaya, Syktyvkar, 167000
