Synthesis and properties of 1,2-dihydro-4(3H)-quinazolinones
- Authors: Khachatryan D.S.1, Belus S.K.1, Misyurin V.A.2, Baryshnikova M.A.2, Kolotaev A.V.1, Matevosyan K.R.3
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Affiliations:
- Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
- N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
- D. Mendeleev University of Chemical Technology of Russia
- Issue: Vol 66, No 6 (2017)
- Pages: 1044-1058
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/240747
- DOI: https://doi.org/10.1007/s11172-017-1852-2
- ID: 240747
Cite item
Abstract
We modified the preparative-scale method for the synthesis of 2-aryl 1,2-dihydro-4(3H)-quinazolinone derivatives obtained in high yields by the reaction of new and commercially available aromatic aldehydes with anthranilic acid amides. A series of quinazolinone derivatives possessing anticancer and antiparasitic activities, as well as capable of preventing the progress of neurodegenerative diseases were characterized. There are grounds for clinical trials of these substances in order to select compounds being promising for clinical application.
About the authors
D. S. Khachatryan
Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Author for correspondence.
Email: derenik-s@yandex.ru
Russian Federation, 3 Bogorodskii val, Moscow, 107076
S. K. Belus
Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Email: derenik-s@yandex.ru
Russian Federation, 3 Bogorodskii val, Moscow, 107076
V. A. Misyurin
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: derenik-s@yandex.ru
Russian Federation, 24 Kashirskoe sh., Moscow, 115478
M. A. Baryshnikova
N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: derenik-s@yandex.ru
Russian Federation, 24 Kashirskoe sh., Moscow, 115478
A. V. Kolotaev
Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
Email: derenik-s@yandex.ru
Russian Federation, 3 Bogorodskii val, Moscow, 107076
K. R. Matevosyan
D. Mendeleev University of Chemical Technology of Russia
Email: derenik-s@yandex.ru
Russian Federation, 9 Miusskaya pl., Moscow, 125047