Identification and determination of antibacterial substances in drugs by capillary electrophoresis
- Authors: Bol’shakov D.S.1, Amelin V.G.1,2, Nikeshina T.B.1
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Affiliations:
- Federal Center for Animals Health
- Vladimir State University
- Issue: Vol 71, No 1 (2016)
- Pages: 94-101
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/181395
- DOI: https://doi.org/10.1134/S1061934815110039
- ID: 181395
Cite item
Abstract
Methods of the quality control of finished dosage forms by capillary zone electrophoresis and micellar electrokinetic chromatography have been proposed. The optimum conditions for the separation and determination of different classes of antibacterial substances, penicillins, fluoroquinolones, nitrofurans, sulfanilamides, metronidazole, and chloramphenicol have been selected. The analytical range for the active ingredients of drugs was 1–1000 mg/g for solid and 0.001–0.50% for liquid drugs. The relative standard deviation of the results of analysis did not exceed 4%.
About the authors
D. S. Bol’shakov
Federal Center for Animals Health
Email: amelinvg@mail.ru
Russian Federation, Yur’evets, Vladimir, 600901
V. G. Amelin
Federal Center for Animals Health; Vladimir State University
Author for correspondence.
Email: amelinvg@mail.ru
Russian Federation, Yur’evets, Vladimir, 600901; ul. Gor’kogo 87, Vladimir, 600000
T. B. Nikeshina
Federal Center for Animals Health
Email: amelinvg@mail.ru
Russian Federation, Yur’evets, Vladimir, 600901