Identification and determination of antibacterial substances in drugs by capillary electrophoresis

Abstract

Methods of the quality control of finished dosage forms by capillary zone electrophoresis and micellar electrokinetic chromatography have been proposed. The optimum conditions for the separation and determination of different classes of antibacterial substances, penicillins, fluoroquinolones, nitrofurans, sulfanilamides, metronidazole, and chloramphenicol have been selected. The analytical range for the active ingredients of drugs was 1–1000 mg/g for solid and 0.001–0.50% for liquid drugs. The relative standard deviation of the results of analysis did not exceed 4%.