Email this article A Novel Method for the Rapid Determination of Isonicotinic Hydrazide in Aqueous Solutions Using Reflectance Spectrophotometry and Colorimetry
- Authors: Zrelova L.V.1, Belyaeva E.I.2, Marchenko D.Y.2, Ivanova E.A.2, Sandzhieva D.A.2, Dedov A.G.2
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Affiliations:
- Sechenov First Moscow State Medical University
- Department of Chemical Technology and Ecology
- Issue: Vol 73, No 3 (2018)
- Pages: 236-242
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182982
- DOI: https://doi.org/10.1134/S1061934818030139
- ID: 182982
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Abstract
A rapid method is developed for the quantitative determination of 5–35 g/L of isonicotinic hydrazide (INH, isoniazide) in aqueous media. The method is based on the formation of copper(I) oxide in the reaction of isonicotinic hydrazide with copper ions on the surface of indicator tablets and the subsequent recording of the analytical signal by reflectance spectrophotometry and colorimetry. Aluminum oxide is proposed as a solid-phase substrate for the production of indicator tablets. Isonicotinic hydrazide can be determined in the tablet form of the Isoniazid preparation.
About the authors
L. V. Zrelova
Sechenov First Moscow State Medical University
Email: dmitrismailr@mail.ru
Russian Federation, Moscow, 119991
E. I. Belyaeva
Department of Chemical Technology and Ecology
Email: dmitrismailr@mail.ru
Russian Federation, Moscow, 119991
D. Yu. Marchenko
Department of Chemical Technology and Ecology
Author for correspondence.
Email: dmitrismailr@mail.ru
Russian Federation, Moscow, 119991
E. A. Ivanova
Department of Chemical Technology and Ecology
Email: dmitrismailr@mail.ru
Russian Federation, Moscow, 119991
D. A. Sandzhieva
Department of Chemical Technology and Ecology
Email: dmitrismailr@mail.ru
Russian Federation, Moscow, 119991
A. G. Dedov
Department of Chemical Technology and Ecology
Email: dmitrismailr@mail.ru
Russian Federation, Moscow, 119991
