A Novel Method for the Rapid Determination of Isonicotinic Hydrazide in Aqueous Solutions Using Reflectance Spectrophotometry and Colorimetry
- Autores: Zrelova L.1, Belyaeva E.2, Marchenko D.2, Ivanova E.2, Sandzhieva D.2, Dedov A.2
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Afiliações:
- Sechenov First Moscow State Medical University
- Department of Chemical Technology and Ecology
- Edição: Volume 73, Nº 3 (2018)
- Páginas: 236-242
- Seção: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182982
- DOI: https://doi.org/10.1134/S1061934818030139
- ID: 182982
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Resumo
A rapid method is developed for the quantitative determination of 5–35 g/L of isonicotinic hydrazide (INH, isoniazide) in aqueous media. The method is based on the formation of copper(I) oxide in the reaction of isonicotinic hydrazide with copper ions on the surface of indicator tablets and the subsequent recording of the analytical signal by reflectance spectrophotometry and colorimetry. Aluminum oxide is proposed as a solid-phase substrate for the production of indicator tablets. Isonicotinic hydrazide can be determined in the tablet form of the Isoniazid preparation.
Sobre autores
L. Zrelova
Sechenov First Moscow State Medical University
Email: dmitrismailr@mail.ru
Rússia, Moscow, 119991
E. Belyaeva
Department of Chemical Technology and Ecology
Email: dmitrismailr@mail.ru
Rússia, Moscow, 119991
D. Marchenko
Department of Chemical Technology and Ecology
Autor responsável pela correspondência
Email: dmitrismailr@mail.ru
Rússia, Moscow, 119991
E. Ivanova
Department of Chemical Technology and Ecology
Email: dmitrismailr@mail.ru
Rússia, Moscow, 119991
D. Sandzhieva
Department of Chemical Technology and Ecology
Email: dmitrismailr@mail.ru
Rússia, Moscow, 119991
A. Dedov
Department of Chemical Technology and Ecology
Email: dmitrismailr@mail.ru
Rússia, Moscow, 119991
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