Heat shock proteins on the surface of tumor cells as a target for anti-tumor therapy
- Authors: Makarova A.O.1,2, Kostenko V.V.1,2, Ovsyanikova O.V.1,2, Svirshchevskaya E.V.1, Lutsenko G.V.1, Sapozhnikov A.M.1
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Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS
- Lomonosov Moscow State University
- Issue: Vol 50, No 3 (2024)
- Pages: 218-230
- Section: Articles
- URL: https://journals.rcsi.science/0132-3423/article/view/261462
- DOI: https://doi.org/10.31857/S0132342324030027
- EDN: https://elibrary.ru/OAKNVU
- ID: 261462
Cite item
Abstract
According to WHO, oncological diseases are the cause of ~5 million people deaths annually. To date, there is no universal solution to fight cancer, despite outstanding achievements in the field of radiotherapy, chemotherapy, and immunotherapy. In this regard, there is a need to develop new approaches to antitumor therapy, in particular based on the search and use of targeted molecules that allow killing tumor cells of various types with high efficiency, without significant toxic effects on healthy organs and tissues. This review presents the characteristics of the main heat shock protein (HSP) families, the features of their expression in tumor cells and the possibility of using monoclonal antibodies to these proteins as a guiding vector for antitumor immunotherapy.
Keywords
Full Text
About the authors
A. O. Makarova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS; Lomonosov Moscow State University
Email: amsap@mail.ru
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997; Leninskie Gory 1, Moscow, 119991
V. V. Kostenko
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS; Lomonosov Moscow State University
Email: amsap@mail.ru
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997; Leninskie Gory 1, Moscow, 119991
O. V. Ovsyanikova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS; Lomonosov Moscow State University
Email: amsap@mail.ru
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997; Leninskie Gory 1, Moscow, 119991
E. V. Svirshchevskaya
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS
Email: amsap@mail.ru
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997
G. V. Lutsenko
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS
Email: amsap@mail.ru
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997
A. M. Sapozhnikov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS
Author for correspondence.
Email: amsap@mail.ru
Russian Federation, ul. Miklukho-Maklaya 16/10, Moscow, 117997
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